烈祝贺老师订购我司ELISA试剂盒，SIC文章发表成功!发表期刊WJG.
发布时间:2023/5/23 14:40:51 阅读次数：429

 烈祝贺老师订购我司ELISA试剂盒，SIC文章发表成功!发表期刊WJG.

WJG在众多消化类期刊中惟一进入SCI-E行列-美国科学情报研究所(Institute for Scientific Information,ISI)2000年度《期刊引用报告》WJG全称是世界胃肠病杂志，被SCI收录了。

文章标题：

P-selectin glycoprotein ligand 1 deficiency prevents development of acute pancreatitis by attenuating leukocyte infiltration

摘要：BACKGROUND Acute pancreatitis(AP) is rapid-onset pancreatic inflammation that causes local and systemic inflammatory response syndrome(SIRS) with high morbidity and mortality, but no approved therapies are currently available. P-selectin glycoprotein ligand 1(PSGL-1) is a transmembrane glycoprotein to initiate inflammatory responses. We hypothesized that PSGL-1 may be involved in the development of AP and would be a new target for the treatment of AP.AIM To investigate the role and mechanism of PSGL-1 in the development of AP.METHODS The PSGL-1 expression on leukocytes was detected in peripheral blood of AP patients and volunteers. Pancreatic injury, inflammatory cytokines expression, and inflammatory cell infiltration was measured in AP mouse models induced with PSGL-1 knockout(PSGL-1-/-) and wild-type(PSGL-1+/+) mice. Leukocyteendothelial cell adhesion was measured in a peripheral blood mononuclear cell(PBMC)-endothelial cell coculture system.RESULTS The expression of PSGL-1 on monocytes and neutrophils was significantly incre

文章中使用我司试剂盒为：IL-1beta elisa kit   IL-6  elisa kit

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